This Open Educational Resource (OER) lab manual was developed at Northern Virginia Community College with financial support from Achieving the Dream. This lab manual includes a Case-Based approach that focuses on encouraging independent work in the laboratory, and enhancing students’ metacognition and problem-solving abilities. This OER Lab curriculum provides relevant, case-based laboratory exercises for the first semester of  Human Anatomy and Physiology, according to the guidelines provided by the Human Anatomy and Physiology Society (HAPS). Exercises focus on histology and articulations and the following systems: integumentary, skeletal, muscular,  and nervous, including special senses. These exercises are appropriate for 100- or 200-level undergraduate anatomy and physiology classes or upper level high school biology classes.